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CreatedOn: 21 Mar, 2024
LastUpdatedOn: 30 May, 2024

Asthma

 

Introduction

Asthma is a common heterogeneous inflammatory chronic disorder of the airways. it is one of the most common chronic diseases in Saudi Arabia, with increasing prevalence. It has significant impact on patients, their families, and the community as a whole in terms of lost work and school days, poor quality of life, frequent emergency department (ED) visits, hospitalizations, and deaths.

The overall prevalence of asthma in children from Saudi Arabia has been reported to range from 8% to 25%, based on studies conducted over the past three decade. This increasing in prevalence of asthma is considered one of the main challenges facing our health systems and society as a whole.

Assessment

Assessment
  1. Take patient History
    • Take the current symptoms - both day and night time.
    • Pattern of symptoms - over a day week or year.
    • Triggers
        • Exercise
        • Allergens (e.g., moulds, pet hair, pollens)
        • Weather (e.g., aspirins, NSAIDs)
        • Occupational exposure
        • Irritants (e.g., cigarettes, cold air, fumes)
        • Viral illness
    • Symptom relief with bronchodilator treatment
    • Impact on work and lifestyle
    • Home and work environment
    • Any presentations to an emergencydepartment, and hospitalor intensive care unit (ICU) admissions.
    • Smoking history - tobacco exposure to other people's smoke.
    • Personal history of allergies, inclusing atopic dermatitis (eczema) or allergic rhinitis.
    • Family history of asthma and allergies.
  2. Physical Examination
    • Measure height and weight.
    • Look for signs of allergic rhinitis, nasal polyps, atopic dermatitis.
    • Examine the chest for deformities (pectus carinatum), wheezes, reduced respiratory sounds, crepitations, heart murmurs.
      • Peripheral airway expiratory wheezing suggesrts asthma, but wheeze may also occur with COPD, viral or bacterial respiratory infection, tracheomalacia, inhaled foreign body,or obesity.
      • High-pitched stridor due to upper airway dysfunction can be mistaken for wheeze.
      • Crepitations suggest an alternate or concurrent diagnosis.
    • Look for clubbing (does not occur in asthma)
    • Therefore a careful considerationsof any alternative diagnoses prior to commencing asthma treatment by a physician should be made.
  3. Perform or arrange pre- and post- bronchodilator spirometry in every patient with suspected asthma. Look for evidence of:
    • Expiratory airflow limitation
      • Expiratory airflow limitation is defined as an FEV1/FVC less than the lower limit of normal for age.

      • FEV1/FVC aged based cut offs:
        • Up to 19 years: < 0.85
        • 20 to 39 years: < 0.80
        • 40 to 59 years: < 0.75
        • 60 years and over: < 0.70
    • Bronchodilator responsive expiratory airflow limitation

      In adults and adolescents , an increase in FEV1 200mL and 12% from baseline 10 to 15 minutes after bronchodilator is a positive bronchodilator response.


  4. Asthma symptom control

    In adults and adolescents, asthma control is based on assessing asthma symptoms, use of reliever medications, and impact on daily activities.

    There are several methods of assessing symptoms control, including:

    • Using an asthma control test

      The ACT is a commonly used tool to assess asthma control. The score of ACT is the sum of the five questions where each is scored from 1 (worst) to 5 (best), leading to a maximum best score of 25. The level of asthma control is categorized into:

      • Controlled: An ACT score of ≥20
      • Partially controlled: An ACT score of 16-19
      • Uncontrolled: An ACT score of <16
      • Asthma Control Test items

       

    • checking history of symptoms based on 4 weeks

Asthma Control Test

         The ACT is a commonly used tool to assess asthma control. The score of ACT is the sum of the five questions where each is scored from 1 (worst) to 5 (best), leading to a maximum best score of 25. The level of asthma control is categorized into:

·      Controlled: An ACT score of ≥20

·      Partially controlled: An ACT score of 16-19

·      Uncontrolled: An ACT score of <16

Asthma Control Test items

Assessment of acute asthma for pediatric depends on PRAM score

The pediatric respiratory assessment measure (PRAM) score

Sign

0

1

2

3

Suprasternal retraction

Absent

 

Present

 

Scalene muscle contraction

Absent

 

Present

 

Air entry

Normal

Decreased at bases

Widespread decreased

Absent/ minimal

Wheezing

Absent

Expiratory only

Inspiratory and expiratory

Audible without stethoscope/ silent chest with minimal air entry

O2 saturation

≥95%

92-94%

<92%

 

Total score of 1-3: low risk and manage in PHC

Total score of 4-7: moderate risk, refer to hospital ER

Total score of 8-12: high risk, refer to hospital ER

Levels of severity of acute asthma in adults

Level

Characteristics

Moderate asthma attacks

·    Increasing symptoms

·    PERF>50-75% best or predicted

·    No features of acute severe asthma

Acute severe asthma

·    Any one of:

o   PEF 30-50% best or predicted

o   Respiratory rate ≥ 25/min

o   Heart rate3 120/min

·    Inability to complete sentences in one breath

Life threatening asthma

·    Any one of the followings in a patient with severe asthma:

o   SpO2 <92% (PaO2, <60 mmHg) on high flow FIO2

o   PEF <30% best or predicted

o   Bradycardia

o   Dysrhythmia

o   Cyanosis

o   Hypotension

o   Normal or high PaCO2

o   Exhaustion

o   Confusion

o   Silent chest

o   Coma

·    Weak respiratory effort

Near-fatal asthma

·    Raised PaCO2 and/or requiring mechanical ventilation

Brittle asthma

·    Type 1: Wide PEF variability (>40% diurnal variation for >50% of the time over a period >3-6 months) despite intense therapy

·    Type 2: Sudden severe attacks on a background of apparently well-controlled asthma

PEF = peak expiratory flow

 

Management

Management of adult - children 

 

Medication

Child dose

Adult dose

Oxygen

Low-flow oxygen is recommended to maintain saturation ≥94%

Low-flow oxygen is recommended to maintain saturation ≥93%

 

Providing 28% oxygen is better than 100% oxygen

Salbutamol

 

Nebulizer solution

 

 

2.5 mg/dose if ≤20 kg body weight

5 mg/dose if >20 kg body weight

 

 

5 mg/dose

 

MDI (100 mcg/puff)

 

4 puffs/ dose ≤20 kg

8 puffs/ dose >20 kg

 

8 puffs/dose

Ipratropium bromide

 

Nebulizer solution

MDI (18 mcg/puff)

 

 

0.25 mg/dose

4 puffs/dose

 

0.5mg/dose

8 puffs/dose

Prednisone (PO)

Prednisone (PO)

Methylprednisolone (IV)

1-2 mg/kg (max.40 mg/day) for 5 days

50 mg/day for 5 days

·      It is recommended to be started as soon as possible preferably within 1 hour of presentation in moderate or severe asthma exacerbation

·      It is usually not necessary to taper the dose unless the duration exceeded 2 weeks

Management of acute asthma for adults and adolescents

 

Request

Patient Segmentation in Adult ≥ 18 years and adolescence >12 years

Level 1 (Visit Primary care facilities only)

·      BA patient had asthma control test ≥ 20

·       PEFR > 80% of predicted personal best

·      Spirometry > 70%

Level 2 (Visit Primary care facilities if not controlled within 6 months referred to secondary care)

·      Asthma control test: 16- 19

·      PEFR: 60 -80 % of predicted personal best

·      Spirometry: 60 - 70 %

Level 3 (Visit secondary care within 2 weeks)

·      Asthma control test:  < 16

·      PEFR: < 60 % of predicted personal best

·      Spirometry: <60 %

 

Patient Segmentation in pediatric under 12 years

Level 1 (Visit Primary care facilities only)

·      Physician assessment of control: 0

·      Spirometry: >70%

Level 2 (Visit Primary care facilities if not controlled within 3 months referred to secondary care)

·      Physician assessment of control:  1-2

·      Spirometry: 60 % - 70%

Level 3 (Visit secondary care within 2 weeks)

·      Physician assessment of control: >= 3

·      Spirometry: <60 %

 

Information

Bronchial Asthma Toolkit

Bronchial Asthma Toolkit